Evaluation Of Hepatoprotective Potential Of Hydroalcoholic Leaf Extract Of Calotropis Gigantea Against Thioacetamide-Induced Hepatic Injury In Wistar Albino Rats

Hepatotoxicity stands as a formidable challenge within the realm of medical science, demanding an in-depth exploration of the intricate interplay between various substances and the liver's vulnerability. The liver, a central metabolic powerhouse, intricately processes an extensive array of compounds, ranging from pharmaceutical drugs to herbal supplements and environmental toxins. Hepatotoxicity unfolds as a complex cascade of events, often involving the formation of reactive metabolites, oxidative stress, and inflammation. The hydroalcoholic extract of Calotropis gigantea demonstrates promising hepatoprotective potential in this experimental model of TAA-induced liver damage. The significant reduction in liver injury markers and the concurrent enhancement of antioxidant defenses suggest a multifaceted protective mechanism. Further research and exploration are warranted to elucidate the specific bioactive compounds responsible for these effects and to determine the translational potential of HECG in mitigating liver damage in clinical contexts. These findings contribute to the understanding of herbal interventions for liver health and may pave the way for the development of novel therapeutic strategies for liver disorders.