Formulation and Evaluation of Tolnaftate Emulgel: A Novel Approach for Enhanced Topical Delivery and Antifungal Efficacy

The present study focuses on developing a tolnaftate emulgel to enhance topical delivery and minimize side effects through targeted application. Utilizing an emulgel method, tolnaftate was formulated with various excipients, including Carbopol 934, propylene glycol, and clove oil as a natural penetration enhancer at different concentrations (1-5% w/w). Comprehensive evaluations were conducted, assessing parameters such as rheology, pH, drug content, skin irritation, washability, drug release, swelling index, antifungal activity against Candida albicans, and stability. Notably, formulation F2 achieved a remarkable 97.45% in vitro drug release within 8 hours and maintained stability over 3 months without significant changes. Skin irritation tests confirmed its safety, while its antifungal efficacy exceeded that of the pure drug and commercial tolnaftate creams. These findings suggest that the tolnaftate emulgel, particularly formulation F2, offers a promising strategy for improved topical delivery, combining enhanced penetration, stability, and antifungal activity.