A Review on Microneedles Based Drug Delivery Strategy

Microneedles (MNs) offer a minimally invasive and effective strategy for drug delivery, particularly for vaccines and other therapeutics. They create microchannels in the skin, allowing drugs to bypass the stratum corneum (the skin's outer layer), which is a major barrier to drug absorption. This approach provides several advantages over traditional methods like injections, including reduced pain, improved patient compliance, and enhanced bioavailability. Pain is a personalized event or body alarm system that can limit a patient's activities and lead to negative repercussions. The commercially available conventional treatment strategies like oral, parenteral, and topical drug delivery systems for pain management are associated with side effects and poor patient compliance. The transdermal route is eminent for its painless distribution. Among transdermal drug delivery system, microneedles (MNs) are gaining attention for their application with delivery at the deeper dermal layer because it bypasses the major barrier of the skin, easily accesses the skin dermal microcirculation, prevents damage to dermal blood vessels, and can be simply inserted into the skin without utilizing any additional applicator devices.