Transferosomes–Ultra Deformable Vesicles for Transdermal Drug Delivery System

Transdermal administration systems have advantages over traditional oral and parenteral delivery methods, they have attracted a lot of attention recently. These self-administered, noninvasive delivery methods have the potential to enhance patient compliance while delivering a regulated release of medicinal substances. The barrier function of the skin's outermost layer presents the biggest hurdle for transdermal delivery methods. Ionized chemicals and molecules with molecular weights more than 500 Da typically cannot cross the skin. As a result, the number of medications that can be provided via this method is restricted. One potential solution to this issue is to encapsulate the medications in transferosomes. Their bilayered shape makes it easier to encapsulate drugs that are both lipophilic and hydrophilic as well as amphiphilic. The present work attempts to explain the idea of ultra deformable vesicular carriers (transferosomes), their mode of action, various synthesis and characterisation techniques, factors influencing their effective delivery of drug into deeper layers of the skin reaching the target site and thus improving its systemic bioavailability.