PARADIGM OF CLINICAL SIGNS OF CHOLESTASIS WHEN DIFFERENTIATING ITS STAGES

The syndrome of intrahepatic cholestasis (SIC) is understood as a slowdown or cessation of bile secretion associated with changes either in its consistency (thickening) or in the lumen of the intrahepatic bile ducts (narrowing) [1–3]. Theoretically, any liver pathology can be complicated by the development of SIC, and only cases with a duration of more than 6 months are classified as chronic. Between the concepts of cholestasis and hepatic jaundice should not put an equal sign. For, the term cholestasis is a broader concept, and hepatic jaundice is just an integral part of it. Moreover, cholestasis can clinically occur with or without jaundice [4,5,6]. It is clear that both forms of cholestasis, even within the same type of liver pathology, can manifest themselves in a different form of its severity [7,8,9].