Emulsomes: An Advancing Nanotechnology for Targeted Drug Delivery Systems and Therapeutics

Lipid-based drug delivery systems have been widely employed over the past few decades for efficient drug delivery. These systems offer several benefits, including protection of drugs from the biological environment, thereby improving their therapeutic efficacy. Various types of lipid-based drug delivery systems have been developed, such as solid lipid nanoparticles, liposomes, emulsions, emulsomes, pharmacosomes, lipospheres, Nano emulsions, niosomes, and transferosomes. Among these, emulsomes have garnered significant attention due to their unique properties, which overcome many limitations associated with other systems. This review emphasizes lipid-based drug delivery systems, with a particular focus on emulsomes. It explores the success of emulsomes as drug carriers, detailing their advantages, structure, and composition, which include a lipid core, antioxidants, phosphatidylcholine, negatively charged particles, surfactants, and cholesterol. Additionally, it outlines various preparation methods for emulsomes, such as lipid film hydration, reverse-phase evaporation, high-pressure extrusion technique, sonication, cast film method, ethanol injection method and detergent removal method, along with their diverse applications.