SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL STUDY OF N-[3-(2 CHLOROPHENYL)-1-PHENYLPROPAN-1-ONE]THIOUREA & N-[3-(4 METHOXYPHENYL)-1-PHENYLPROPAN-1-ONE]SEMI CARBAZIDE

Mannich reaction is a useful method for the preparation of β-amino carbonyl compounds, which are useful intermediates for the preparation of β-aminoacids. The Mannich reaction is an example of nucleophilic addition of an amine to a carbonyl group followed by dehydration to the Mannich base. Development of an efficient method for the preparation of β-amino carbonyl compounds is thus highly desired. To achieve our objective, we identified the following Mannich bases as core entries and they have been subjected to variety of chemical reaction under different conditions. In this work we synthesized and characterized N-[3-(4-methoxyphenyl)-1-phenylpropan-1-one]thiourea (1) & N-[3-(2-chlorophenyl)-1-phenyllpropan-1-one]semicarbazide (2). The synthesized compounds were characterized by FT-IR, 1H NMR and Mass techniques.