Current and Promising Histone Deacetylase Inhibitors in Cancer Therapy

<p><strong><span>Abstract:</span></strong><span> Cancer is the most critical disease distressing humans and a primary cause of death on a global scale. Lately, the use of targeted anticancer medications as an approach for optimizing antitumor therapy has been urged. Changes in epigenetics in eukaryotic biological processes can result in the up- or downregulation of regulatory proteins contributing to disease onset and progression. Histone deacetylases (HDACs) have been one of the most researched epigenetic targets over the past three decades, also, HDAC enzymes are promising drug targets for the treatment of cancer. Truly, abnormal HDAC expression is associated with various kinds of cancer and neuro-degenerative disorders, establishing HDACs promising molecular targets for the design of new drugs. Numerous HDAC inhibitors (HDACIs) are currently in clinical evaluation for different forms of cancer, and some of them have reached the market following food and drug administration (FDA) approval. This review summarizes the various HDAC classes and discuss different classes HDACIs with a dedicated focus on late-stage preclinical candidates and drugs in clinical trials. Lastly, but just as importantly, we shed light on the future directions in HDACIs design which may help researchers in development and discovery of new horizons in cancer treatment.</span></p> <p><strong><span>Keywords:</span></strong><span> Cancer, Clinical trials, Histone deacetylases, HDAC inhibitors.</span></p> <p><strong><span>Title:</span></strong><span> Current and Promising Histone Deacetylase Inhibitors in Cancer Therapy</span></p> <p><strong><span>Author: </span></strong><span>Heba A. Hofny, Mamdouh F.A. Mohamed, El-Shimaa M. N. Abdelhafez, Heba A. Hassan, Gamal El-Din A. Abuo-Rahma</span></p> <p><strong><span>International Journal of Novel Research in Physics Chemistry & Mathematics</span></strong></p> <p><strong><span>ISSN 2394-9651</span></strong></p> <p><strong><span>Vol. 12, Issue 1, January 2025 - April 2025</span></strong></p> <p><strong><span>Page No: 35-52</span></strong></p> <p><strong><span>Novelty Journals</span></strong></p> <p><strong><span>Website: www.noveltyjournals.com</span></strong></p> <p><strong><span>Published Date: 03-</span></strong><strong><span>March</span><span>-2025</span></strong></p> <p><strong><span>DOI: </span></strong><span><a href="https://doi.org/10.5281/zenodo.14959413"><strong><span>https://doi.org/10.5281/zenodo.14959413</span></strong></a></span></p> <p><strong><span>Paper Download Link (Source)</span></strong></p> <p><strong><span><a href="https://www.noveltyjournals.com/upload/paper/Current%20and%20Promising%20Histone-03032025-2.pdf">https://www.noveltyjournals.com/upload/paper/Current%20and%20Promising%20Histone-03032025-2.pdf</a></span></strong></p>