Screening Of Neuropharmacological Activity Of Herbal Extract

The abstract summarizes research on neurodegenerative disorders, focusing on memory impairment and the potential neuroprotective effects of Hedychium coronarium Linn. Essential oil. Neurological disorders like Alzheimer’s disease involve cognitive decline and are linked to cholinergic system deficits and oxidative stress. Scopolamine-induced amnesia models were used to evaluate memory performance in mice treated with essential oil via inhalation and oral routes, alongside a standard drug (Donepezil). Behavioral tests (Elevated Plus Maze, Pole Climbing Test) and biochemical assays (AChE activity, MDA, GSH levels) demonstrated significant improvements in memory and reduction in oxidative stress markers with essential oil treatment. These findings suggest Hedychium coronarium Linn. essential oil could be a potential therapeutic agent for managing neurodegenerative disorders associated with memory impairment.