Study on Utility of Serum LDH, Creatinine Kinase, Albumin, APPT and Aminotransferases as Predictive Markers of Severe Dengue in Adults

Background: This study aims to develop predictive markers for early detection and management of dengue, a significant arthropod-borne viral disease, to overcome challenges in distinguishing between severe and mild forms of the disease. Aim: The study investigates the correlation between biochemical markers like serum LDH, Creatinine kinase, Albumin, aPTT, and aminotransferases and their use as predictive indicators of severe dengue in adults. Methodology: The research is conducted on patients admitted to the Government Erode Medical College Hospital, Perundurai, throughout a one-year period (December 2023 to October 2024). This research was executed. As a prospective clinical research, written informed permission will be obtained prior to the investigation, after the provision of comprehensive information to the participants about the study. Patients with dengue fever will be evaluated for biochemical indicators including serum LDH, creatinine kinase, albumin, aPTT, SGOT, SGPT, and serum albumin by laboratory studies and clinical manifestations. Results: Biomarkers like Lactate Dehydrogenase, Creatine Kinase, aPTT and aminotransferases are elevated and albumin is reduced in severe dengue. Conclusion: Serum LDH, Creatine kinase, serum albumin, aimnotransferases, and aPTT should be evaluated during admission and early illness in patients with fever with thrombocytopenia to identify and treat severe cases of dengue fever, reducing mortality rates.