Formulation And Evaluation of Topical Drug Delivery System Containing Niosomal Gel

Novel drug delivery System, like niosomes, extend the drug's shelf life and efficacy by shielding it from environmental influences and enzymatic destruction. By using different concentration of polymers, the formulation and evaluation of chlorpheniramine niosomes has been prepared by using ether injection method. A14 gauge needle was selected for preparation of formulation. Pre-formulation analysis uses FTIR to ensures the drug purity and its compatibility with excipients. The gel, however, exhibit some instability in accelerated conditions (40°C), suggesting that higher temperatures may have an impact on the formulation's long-term stability. The chlorpheniramine niosomal gel's pH was found to be approximately 5.9, which is within acceptable range for topical application. The maximum cumulative drug release (93.25%) in 8 hours and hence it is the best formulation.