Navigating Oral Health in Autoimmunity: A Case of Systemic Lupus Erythematosus with Oral Ulcerations

Abstract Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which can affect multiple organs and tissues throughout the body. SLE generally has an involvement of oral cavity and quality of life is impacted due to the disease process. A 50-year-old female presented with a complaint of painful oral lesions. Clinical examination revealed multiple ulcerative lesions on the buccal mucosa and the hard palate. The patient also reported a recent flare-up of rashes on sun exposed area as well as joint pain, fever and fatigue. Incisional biopsy was done. Histopathological analysis confirmed the presence of characteristic features of auto-immune disorder, including degeneration of the basement membrane and lymphocytic infiltration. A diagnosis of SLE was made. The oral lesions were conservatively managed which led to significant improvement. The case highlights the importance of recognizing oral manifestations of SLE for timely and effective management.