Signal Transduction Pathways in Candida albicans: A Focus on MAPK regulation during infection

This publication investigates the Mitogen Activated Protein Kinase (MAPK) pathways within Candida albicans, focusing on their roles in responding to environmental stresses such as osmotic pressure and oxidative stress. It details how these signaling pathways coordinate yeast-hypha morphogenesis while regulating virulence factors essential for survival within host environments. Specific attention is given to the Hog1, Mkc1, and Cek1 pathways—highlighting their mechanisms of action through various membrane sensors and their impact on immune evasion strategies against host defenses. Understanding these pathways provides valuable insights into potential therapeutic targets for managing candidiasis.