DEVELOPMENT OF AN EXPRESS METHODOLOGY FOR ASSESSING THE QUALITY OF ALPHA-LIPOIC ACID BEFORE DISSOLUTION AND FILTRATION USING THE METHOD NIR

Abstract Alpha-lipoic acid (ALA, thioctic acid), a diethyl compound that is enzymatically synthesized in the mitochondria from octanoic acid, an essential naturally occurring dithiol compound, has become a common ingredient in many pharmaceutical products and nutritional supplements used in disease-dependent pathologies. oxidative stress. It performs the functions of a cofactor for mitochondrial ketoacid dehydrogenases, which determines its important role in the energy metabolism occurring in mitochondria. The bioavailability of ALA when taken orally is limited by pharmacokinetic features that reduce its therapeutic effectiveness (reduced solubility, insufficient stability in the stomach and breakdown in the liver, doubled by drug retardations). The purpose of the research was to develop an express method for quality control of alphalipoic acid based on the indicator - ability to dissolve and filter. It is important to provide a drug with in vitro dissolution comparable to Rapid Lifetime Determination (RLD) is a mathematical method for extremely rapid lifetime estimation in exponential decays that allows the compound to reach a target level to provide the optimal claimed antioxidant activity of ALA at the cellular level. even for food supplements. The NIR method can be used to control the relevant properties of the material, to provide certain chemical and physical information. This information can be obtained quickly, with virtually no sample preparation, which is an advantage over many other methods.