A Review on Recent Advances of Pharmacological Diversification of Thiophene Derivatives

The heterocyclic compounds have great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are thiophenes possessing wide spectrum of biological properties like anti-cancer, anti-inflammatory, anti-bacterial, anti-fungal, anti-tumor, anti-malarial, anti-microbial, anti-anxiety and many more activities. This skeleton is an important pharmacophore considered as a privileged structure. This review highlights the recent advances in the synthesis of thiophene derivatives with wide variety of pharmacological activities.