Formulation And Evaluation of Mupirocin Loaded Liposomes by Design Expert Software

This study aimed to develop and optimize Mupirocin liposomes for wound healing using a 3^2 full factorial design. The design involved two independent variables, cholesterol and phospholipon 90H, and three dependent variables, percent yield, particle size, and polydispersity index (PDI). The optimized formulation showed a percent yield of 72.87%, particle size of 264.30 nm, and PDI of 0.233. The in vitro release study revealed a diffusion-controlled mechanism, with 95.43% of the drug released within 12 hours. The optimized liposomes were spherical in shape and had a vesicular structure. The study demonstrated the importance of optimizing liposomal formulation for improved wound healing outcomes. The results of this study can be used to develop a topical treatment for wound infections, providing a promising approach for the management of this debilitating condition.