mRNA-BASED THERAPEUTICS BEYOND VACCINES: APPLICATIONS IN ONCOLOGY

Messenger RNA (mRNA) therapeutics grabbed the world's attention duringthe COVID-19 pandemic vaccine development, but the potentials of mRNAvaccines go much beyond infectious diseases and into oncology. The reviewthus showcases how mRNA technology can revolutionize the field of cancermedicine as well. Applications include therapeutic cancer vaccines, mRNAencoding for immune-modulatory agents such as cytokines and monoclonalantibodies, and the modification of immune cells, such as CAR-T cells.Since mRNA can mount targeted and very powerful immune responses andalso has a form of adaptability for personalized medicine, it truly presentsmRNA as a suitable tool against a vast range of malignancies. The reviewfurther explores new delivery technologies, clinical evaluations, real-worldapplications, and the current hurdles of stability, delivery, and tumorheterogeneity. With more and more therapeutic mRNA advancing rapidly,oncology is witnessing the coming of a new wave that centers aroundprecision, efficacy, and least system toxicity. Explore further andemphasizes the need for continued investigation and collaboration to harnessthe mRNA therapeutic potential in cancer therapeutics fully.