Comparison of Pre Emptive-Analgesic Efficacy of Oral Flupritine with Oral Clonidine in Diagnostic Laparoscopy

Objective: Post operative pain remains a problem worldwide, resulting in delayed post operative mobility and recovery. The aim of this study was to compare analgesic efficacy of oral flupirtine maleate with oral clonidine in diagnostic laparoscopy for gynaecological procedures. Material and Methods: This is hospital based, randomised, double blind, comparative study. After receiving approval from ethical committee, 50 cases were allocated to two groups using sealed envelope method to receive capsule flupirtine (200 mg) or clonidine (0.2 mg) orally, 1 hr prior to surgery with a sip of water. Mean of total number of rescue analgesia required, median visual analog scores(VASs) at 0, ½, 1, 2,4, 6 hr post operatively were compared and analysed by using non parametric Mann Whitney U test using primer version 7 software. Results: VAS score was lower during entire duration of study in flupritine group having significant difference at 4 & 6 hrs. Requirement of rescue analgesia was comparable in both groups. Conclusion: Flupritine is superior to clonidine as it provide long duration of post operative analgesia without causing significant changes in hemodynamic variables and better tolerance to patient.