PROGNOSTIC SIGNIFICANCE OF p53 AND ki67 EXPRESSION IN CERVICAL CANCER

A low level of Ki-67 expression was found in 53 (44.2%) patients, intermediate in 22 (18.3%) and high in 45 (37.5%). Low expression of the mutant protein p53 was detected in 53 (44.2%) women, moderate in 19 (15.8%) and high in 48 (29%). Proliferative activity proved to be the most prognostic factor (in terms of the proportion of Ki-67-positive cells), as with an increase in this indicator by 1 point, the overall survival decreased by 0.99 times. A multivariate analysis of the combined effect of the studied oncogenes on overall survival, considering the extent of tumor spread, allowed us to develop a formula for predicting the risk of disease progression in each individual case.