Prognostic Significance of High-Sensitivity C-Reactive Protein in Acute Myocardial Infarction: Cardiovascular Outcomes in Diabetic and Non-Diabetic Patients

High-sensitivity C-reactive protein (hs-CRP) is one among the widely studied risk factors among systemic markers of inflammation with growing significance in the prognosis of acute myocardial infarction (AMI). This review integrates findings from various studies assessing the role of hs-CRP in predicting cardiovascular outcomes in AMI patients, with and without diabetes mellitus (DM). Elevated hs-CRP levels were consistently associated with increased risks of heart failure, arrhythmias, reinfarction, and mortality. Diabetic patients exhibited higher baseline hs-CRP levels and a greater incidence of complications. Notably, hs-CRP remained an independent predictor of major adverse cardiovascular events (MACE) across several studies, beyond traditional risk scores. These findings support the clinical utility of hs-CRP in early risk stratification and outcome prediction following AMI, particularly in patients with DM.