Formulation And Evaluation of Topical Polyherbal Emulgel for Treatment of Eczema

Atopic dermatitis, commonly known as eczema, is a chronic inflammatory skin condition affecting millions worldwide. Characterized by itching, redness, and dryness, it significantly reduces quality of life and often requires long-term management. Conventional treatments such as corticosteroids, antihistamines, and immunosuppressants offer symptomatic relief but pose risks including side effects, dependency, and high costs. As a result, interest in herbal alternatives has increased due to their safety and potential efficacy.Neem (Azadirachta indica) and Aloe vera (Aloe barbadensis miller) are recognized for their antibacterial, anti-inflammatory, and skin-soothing properties, making them suitable candidates for eczema treatment. This study aims to formulate and evaluate a neem and aloe vera-based emulgel by leveraging emulgel technology, which combines the benefits of emulsions and gels to enhance drug stability, penetration, and ease of application.The formulation process involved optimizing ingredient concentrations and assessing various physicochemical properties, including pH, viscosity, spreadability, and in-vitro drug release. Additional evaluations were conducted to assess skin irritation potential and product stability under different environmental conditions.Preliminary findings suggest that the neem-aloe vera emulgel demonstrates favorable stability, good skin retention, and potential therapeutic benefits for eczema management. By addressing the limitations of traditional therapies, this formulation offers a safer, cost-effective, and natural alternative for dermatological use. However, further studies and clinical trials are necessary to confirm its long-term safety and therapeutic effectiveness.