The Potential Involvement of Interleukin-18 and Interleukin-10 in Rheumatoid Arthritis Patients

Rheumatoid arthritis, a common chronic disease that may lead to severe obstruction, requires early diagnosis and appropriate treatment, and disruption of regulation in the cytokine network plays a crucial role in the development of this disease. Understanding the role of cytokines can have a significant positive impact on the lives of patients, as technological advances have allowed the introduction of customized treatments targeting cytokines, such as anti-TNF-alpha, IL-1 and IL-6 drugs. In addition, there is increasing interest in the potential participation of interleukin-18 and interleukin-10 in patients with rheumatoid arthritis. This study aimed to measure interleukin-18 and interleukin-10 in the serum of rheumatoid arthritis patients to enhance the detailed understanding of the balance of cytokines in improving the diagnosis and treatment processes and how these cytokines affect the course of the disease and considered potential strong vital indicators of rheumatoid arthritis. The study was conducted with 70 patients of rheumatoid arthritis who reviewing the rheumatoid rheumatic disease unit at Marjan Hospital in Babylon province. All patients were diagnosed with the disease by a rheumatologist, and 40 healthy people as control group in the study. Serum cytokine levels were measured using an ELISA kit. The results of the study showed increased serum levels of Interleukin-18 (p< 0.05) and Interleukin-10 (p< 0.05) were significantly higher in patients with rheumatoid arthritis compared to the healthy control group. study's results indicate that patients with rheumatoid arthritis have elevated serum levels of both interleukin-18 and interleukin-10 compared to the healthy group.