PHARMACOLOGICAL AND WOUND HEALING PROPERTIES OF TRIDAX PROCUBENS

Wound healing is a complex biological process involving the restoration of cellular, anatomical, and functional integrity following injury. The process can be hindered in certain conditions, such as diabetes mellitus, which is known to impair wound healing, resulting in chronic wounds. This poses a significant health burden globally. While traditional treatments exist, their effectiveness is not always guaranteed, and there is a growing need for more reliable therapeutic alternatives. This paper explores the potential repurposing of existing drugs—such as dipeptidyl peptidase 4 (DPP4) inhibitors, metformin, statins, and phenytoin—as treatment options for chronic wounds, based on preclinical and clinical findings. In addition to pharmaceutical approaches, traditional herbs have been widely utilized for wound healing, with Tridax procumbens (TP) emerging as a promising candidate. Known for its antimicrobial, anti-inflammatory, and antioxidant properties, TP accelerates wound healing through various mechanisms. TP has shown potential in treating a wide range of conditions, including infections, inflammation, and skin wounds. Its chemical constituents, such as flavonoids (quercetin, luteolin, apigenin), contribute to its wound-healing properties by reducing oxidative stress and inflammation. TP’s medicinal uses extend beyond wound care, encompassing liver protection, pain relief, antidiabetic effects, and antimicrobial activity, among others. Key Points :-Wound Healing Process ,. Chronic Wounds, Tridax Procumbens (TP) , Wound Healing Mechanisms , Antimicrobial & Antidiabetic