Formulation and Characterization of Herbal Tablets for the Management of Anti-microbial Activity

Tablets were formulated using Euphorbia hirta plant extract through the wet granulation technique. In this study, the aerial parts of Euphorbia hirta were used for the preparation of herbal tablets. The extract was obtained by maceration followed by soxhlet extraction methods, then dried and blended. After extraction, the dried herbal material was mixed with pharmaceutical excipients such as diluents, binders, super disintegrants, and lubricants to prepare granules. The prepared granules were evaluated for their physical properties, including the Angle of repose, Bulk and tapped density, Carr’s Index, Hausner’s Ratio, Void volume. These granules were then compressed into tablets of specific size and shape using a tablet punching machine. Once the tablets were prepared, they were tested for various evaluation parameters such as Physical appearance, Weight variation, Friability, Disintegration time, Hardness, Thickness, Flavour and taste for patient acceptability. The formulated Euphorbia hirta tablets showed acceptable physical properties such as uniform weight, hardness, and rapid disintegration time. Additionally, the extract exhibited significant antimicrobial activity, indicating its potential effectiveness against common bacterial strains.