FORMULATION AND EVALUATION OF BOSENTAN SUSTAINED RELEASE TABLETS

The aim of the present study was to develop sustained release formulation of Bosentan to maintain constant therapeutic levels of the drug for over 8 hrs. Various synthetic polymers were employed as polymers. Bosentan dose was fixed as 62.5 mg. Total weight of the tablet was considered as 200 mg Polymers were used in the concentration of 31.5,41.25,62.5 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. And the drug and excipient compatibility studies showed that there is no interaction between the drug and polymers employed in the formulation. Whereas from the dissolution studies it was evident that the formulation F3, showed better and desired drug release pattern i.e.,98.13 respectively % in 8 hours.