Design and Assessment of Mucoadhesive Insitu Gel Forming Spray for Oral Delivery of Ibuprofen

The present study was aimed to develop an insitu gel forming spray for local release of Ibuprofen in the buccal cavity to improve the analgesic effect of NSAID drug which has poor water solubility. The formulations were introduced to the oral cavity as a spray to improve compliance and for easier administration. In this work, two grades of Carbopol (934 and 940)-based in situ gel spray were designed. The formulations containing Ibuprofen spray prepared by mixing different concentrations of Carbopol with xanthan gum. Four formulations were investigated and evaluated for pH, gelation capacity, spray angle, rheological properties, and release study. The prepared formulations undergo gelation after it had been actuated to the buccal cavity as a spray solution. The results showed that, as the concentration of polymer was increased, the release of drug decreased and the viscosity increased for both grades. The in situ gel containing 0.3% Carbopol 934 and 0.2% xanthan gum regarded as a better candidate which had a good gelation and release property compared to other formulations.