EXPLORING MUCOSAL PATHWAYS FOR DRUG DELIVERY: FROM DESIGN TO CLINICAL APPLICATIONS

Mucoadhesion is defined as, the attachment of two materials, at least one of which is a mucosal surface, is frequently referred to as mucoadhesion. Mucoadhesive dosage forms can be made to allow for extended retention at the application site, resulting in a regulated rate of drug release for better therapeutic results. Drug molecules that are not suitable to the oral route, such as those that undergo acid degradation or substantial first-pass metabolism, may benefit from the application of dosage forms to mucosal surfaces. A number of variables, such as the type of mucosal tissue and the physicochemical characteristics of the polymeric formulation, affect a dosage form's capacity to adhere to mucosal tissue. The ability of a dosage form to stick to mucosal tissue depends on several factors, including the kind of mucosal tissue and the physicochemical properties of the polymeric formulation.