EVALUATION OF THE EFFECTIVENESS OF SODIUM CARBOXYMETHYLCELLULOSE IN THE PREVENTION OF POSTOPERATIVE ADHESION FORMATION USING HYDROXYPROLINE AND MATRIX METALLOPROTEINASES AS BIOMARKERS OF FIBROGENESIS

Postoperative intra-abdominal adhesions remain a critical challenge in abdominal and pelvic surgery, with significant clinical and economic implications. Adhesions can lead to chronic pelvic pain, female infertility, intestinal obstruction, and complicate reoperations due to anatomical distortion. The development of adhesions is a multifactorial process involving peritoneal injury, local inflammation, oxidative stress, and dysregulated collagen metabolism. Despite preventive surgical techniques, the incidence of adhesions remains high, highlighting the need for effective adjunctive strategies.