CLINICAL AND MICROBIOLOGICAL FEATURES OF MULTIDRUG-RESISTANT PULMONARY TUBERCULOSIS IN PATIENTS WITH COMORBID CONDITIONS

Multidrug-resistant pulmonary tuberculosis (MDR-TB) remains a significant global health challenge, particularly in patients with comorbid conditions that complicate diagnosis and treatment. This study investigates the clinical manifestations, microbiological characteristics, and treatment outcomes of MDR-TB in patients with associated diseases. A cohort of 120 patients with confirmed MDR-TB was analyzed, of whom 58 had one or more comorbid conditions, including diabetes mellitus, chronic obstructive pulmonary disease (COPD), HIV infection, and cardiovascular diseases. The study found that comorbidities altered the clinical presentation of MDR-TB, often leading to atypical radiological patterns and prolonged bacterial persistence. Microbiological analysis revealed higher rates of extensive drug resistance and delayed sputum conversion in patients with comorbidities. Treatment outcomes were less favorable in this group, with increased rates of treatment failure and adverse drug reactions. The findings underscore the need for individualized treatment strategies and integrated care approaches for MDR-TB patients with comorbid conditions to improve clinical outcomes.