Anti-Proliferative Effect of Methanolic Extract from Philodendron Burle-Marxii

Cancer remains one of the leading cause of death and demands better therapeutic agents for its management. Different plant genus remains a source of chemotherapeutic agents. Philodendron is such a genus having immense medicinal potential. The species Philodendron bipinnatifidum is reported to have different pharmacological actions which is due to the presence of flavonoids and terpenoids. Philodendron burle-marxii is also a species in the Philodendron genus having similar phytochemicals. But biological potential of this species is not explored. In this study anti-proliferative effect of methanolic extract from Philodendron burle-marxii leaves were conducted through MTT assay, Chick chorioallantoic membrane assay, Comet assay. The methanolic extract has significant cytotoxic effect and it can also inhibit angiogenesis. The comet assay suggests the anti-proliferative actions may be due to its DNA damaging effect. This finding suggest the therapeutic of Philodendron burle-marxii.