Synthesis Of Schiff Bases Of Indole-3-Carboxaldehyde Derivatives Using Biginelli Reaction And Their Antioxidant Evaluation

A series of Schiff bases of indole-3-carboxaldehyde were synthesized using biginelli reaction and examined for their antioxidant potential to probe the most potent analogues using two in vitro models like 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Through the compounds showed various degree of activity whereas, compound (DP-2 and DP-4) shows superior antioxidant activity relative to other examined derivatives and also exhibit more activity than the standard, Ascorbic acid (AA).

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2024-10-05
DOI
https://doi.org/10.5281/zenodo.13893971
Primary Topic
Synthesis and biological activity
Type
article
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article

Synthesis Of Schiff Bases Of Indole-3-Carboxaldehyde Derivatives Using Biginelli Reaction And Their Antioxidant Evaluation

Zenodo (CERN European Organization for Nuclear Research)
Synthesis and biological activity
article

Synthesis Of Schiff Bases Of Indole-3-Carboxaldehyde Derivatives Using Biginelli Reaction And Their Antioxidant Evaluation

article en

Abstract

A series of Schiff bases of indole-3-carboxaldehyde were synthesized using biginelli reaction and examined for their antioxidant potential to probe the most potent analogues using two in vitro models like 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Through the compounds showed various degree of activity whereas, compound (DP-2 and DP-4) shows superior antioxidant activity relative to other examined derivatives and also exhibit more activity than the standard, Ascorbic acid (AA).

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 63%
Synthesis and biological activity
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Synthesis Of Schiff Bases Of Indole-3-Carboxaldehyde Derivatives Using Biginelli Reaction And Their Antioxidant Evaluation · Zenodo (CERN European Organization for Nuclear Research) (2024) | TGRS Research Map | TGRS