Analysis of Anticonvulsive Benefit of Dibenzylidene Derivative; 2, 6 (4-Dimethylaminophenyl) Methylidene Cyclohexan-1-One) In Wistar Rat Model of PTZ - Induced Seizure

This study was designed using pentylenetetrazol - induced seizure in rats to assess the attenuating effect of a derivative of Dibenzylidene (designated as D2) on convulsive behaviour. Twenty-five (25) Wistar rat weighing about 100-280g were randomly divided into five groups; Group 1 was the control group, group two, three and four were given D2 as pretreatment while group five was given diazepam which served as the standard. The solutions were given according to the calculation of the weight of the rat and stock of the drug to get the dosage. After one hour of pretreatment the pentelenetetrazol (PTZ) solution was given to each of the five groups by intraperitoneal route to induce seizure and observed keenly for convulsive behaviours. The results showed that longer time was required for the onset of seizure in D2 administered rats compared to the control group which was not pretreated. Also group one recorded more death than the other groups. It may be inferred from the observation that D2 can be beneficial in reducing seizure severity and duration in Wistar rat.