Effect of Hyperbaric Oxygen Therapy on Insulin Resistance in PostMenopausal Women: A Randomized Assessor-Blinded Controlled Trial

Background: In postmenopausal females, Insulin resistance is commonlyencountered in clinical setting. Hyperbaric oxygen therapy has been proposedeffective in lowering blood glucose level and improving function.Identification of clinical examination variables as predictors to blood glucoselevels and dysfunction would offer therapists the chance to undertake clinicaldecisions and consequently improve treatment efficiency. Objectives: toexamine the effect of hyperbaric oxygen therapy on insulin resistance inpostmenopausal women. Patients and methods: This Predictive validity,diagnostic study included fourty postmenopausal participants with insulinresistance recruited from Kobry el Koba Military Complex with age 55-65years, Their BMI was 30-34.9 kg/m. They were equally divided randomly into:group (A) who received Hyperbaric Oxygen therapy 5sessions per week for30 consecutive sessions in addition to their oral hypoglycemic drugs. Group(B) who received their oral hypoglycemic drugs only. Participants in group(A)were assessed for fasting blood glucose level by glucometer, ACCU-Chekperforma, before treatment and post the 1st 10 sessions and post the 2nd 10sessions while both groups were assessed for HgA1C level by blood sample ,Health related quality of life by Quality of life enjoyment and satisfactionquestionnaire QLES-QSF pre- and post-treatment sessions. Results: Posttreatment, both groups showed a significant decrease in HbA1c levels and anincrease in QLES-QSFB, Group A showed a significantly greater decrease inHbA1c levels and a significantly greater increase in QLES-QSFB comparedto group B (p<0.001). In group A,after both 10 and 30 sessions, there was asignificant decrease in fasting blood glucose (FBG)levels compared to pretreatment levels (p<0.001).Additionally ,FBG levels significantly decreasedafter 30 sessions compared to after 10 sessions (p<0.001). Conclusion:Hyperbaric oxygen therapy was effective in managing insulin resistance inpostmenopausal women.