Formulation And Evaluation of Harbel Gel of Berberis Aristata for Anti-Psoriatic Activity

Introduction: Psoriasis is a widespread chronic disease affecting 1-3% of total population and in most cases, treated by topical application of creams & gels. The oral route is evidence for harsh side effects because of systemic immuno suppression which can be avoided by topical route. Though, the topical route is very demanding because of the physicochemical nature of diseased stratum corneum and so no, single treatment works for every patient. Method: Berberis aristata loaded herbal gel was formulated by modified techniques and characterized by pH, stability, spreadability, viscosity, skin irritation, gelling property. Other formulations like ointment and cream are available in the market for the treatment of psoriasis so we prepared the gel which is not available in the market as it is most convenient to apply and cost-effective as it is herbal. Result: The gel was made using the fusion method, which ensured that the herbal extract and gel base were mixed uniformly and remained stable throughout storage. It helps to enhance spreadability, adhesion, viscosity and provides stability. The gel was made using the fusion method, which ensured that the herbal extract and gel base were mixed uniformly and remained stable throughout storage. It helps to enhance spreadability, adhesion, viscosity and provides stability. Conclusion: The present research work shows that, herbal gel of B. aristata is having effective antipsoriatic activity because of the presence of constituent berberine which has been proved on the basis of different evaluation parameters for gel. Gel was evaluated for different parameters such as appearance, feel on application, pH, and viscosity. It has concluded that the above-selected formulation was stable, effective and convenient with pleasant organoleptic properties.