Formulation And Evaluation of Fast Disintegrating Tablet of Betaxolol Hydrochloride Using Super Disintegrants

The study focused on developing a fast-disintegrating oral tablet of Betaxolol Hydrochloride aimed at treating hypertension through a direct compression method. Various formulations were tested using different concentrations of super disintegrants, with Microcrystalline cellulose serving as the diluent. Mannitol was utilized as a directly compressible diluent, while aspartame was chosen for its intense sweetness. Additionally, magnesium stearate and talc acted as lubricants, and aerosil was included to enhance flow properties. Pineapple flavor was added to improve the tablet's palatability. The evaluation of the tablets included assessments of thickness, weight variation, friability, hardness, content uniformity, wetting time, water absorption ratio, disintegration time, in vitro dissolution time, and dispersion time. The formulation labeled MF9, which contained 5.3% Cross Carmellose Sodium, emerged as the optimized batch due to its rapid disintegration time of just 26 seconds and an impressive drug release of 99.59% within 3 minutes. Fourier Transform Infrared (FT-IR) analysis confirmed no incompatibility between the drug and the excipients used. Differential Scanning Calorimetry (DSC) results indicated no significant alterations in peak characteristics, suggesting a lack of chemical interaction among the components. This indicates that the fast-disintegrating oral tablet of Betaxolol Hydrochloride could be a valuable formulation for hypertension treatment where a quick onset of action is essential.