Development and Evaluation of Sustained Release Matrix Tablet of Naproxen Using Natural Polymer

The present study aims to develop sustained-release matrix tablets of Naproxen using Moringa oleifera gum, a natural polymer, for its release-retarding properties, and with the synthetic polymer HPMC K-100. Compatibility study between the drug and the selected polymers was confirmed through FTIR spectroscopy. Matrix tablets were prepared using the wet granulation method. The granules were assessed for bulk density, tapped density, compressibility index, Hausner’s ratio, and angle of repose, all of which were found within acceptable limits. The compressed tablets were evaluated for physical parameters including thickness, hardness, friability, weight variation, drug content, in vitro drug release, and stability. All formulations complied with Pharmacopeial standards. In vitro dissolution studies conducted over a 12-hour period for nine formulations (F1–F9) demonstrated that formulations F5 and F3 exhibited optimal sustained-release profiles, releasing 98.69% and 97.8% of the drug, respectively. Stability studies of formulation F3 indicated no significant changes, confirming its stability over the test period.