Comprehensive Evaluation of Medicinal Fruit Plants Carica Papaya and Psidium Guajava

This study investigates the biological activities of aqueous extract from the leaves of Carica papaya (C. papaya) and Psidiumguajava (P. guajava), focusing on their phytochemical composition and therapeutic potential, including antioxidant, anti-diabetic, anti-arthritic, anti-microbial, and wound healing properties. Phytochemical analysis revealed the presence of bioactive compounds such as alkaloids and phenols. Anti-oxidant screening demonstrated significant free radical scavenging activity for both the extracts. Both C. papaya andP. guajava exhibited promising anti-diabetic activity through notable inhibition of the enzyme alpha-amylase. Furthermore, the anti-arthritic potential of the extracts was evident from their ability to inhibit protein denaturation. However, anti-microbial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans revealed no zone of inhibition. In wound healing assays, C. papaya extract significantly enhanced cell migration in L929 fibroblast cells, whereas P. guajava extract exhibited a slower rate of cell migration. These findings underscore the therapeutic potential ofC. papaya and P. guajava leaf extracts as natural remedies with multifaceted biological activities, warranting further investigation for clinical applications.