Comparison of Antioxidant Vitamins and Enzymes in Patients with Alcoholic Liver Disease in North Karnataka Population

Background: Liver is the major site for metabolism. Ingestion of alcohol produces striking metabolic imbal-ances in the liver, causing the formation of Reactive Oxygen Species (ROS). Inadequate removal of ROS may cause cell damage, attacking lipo-proteins and inactivating enzymes. Method: 95 Alcoholic liver disease patients were compared with the same number of healthy (control) groups. Clinical and laboratory investigations were carried out using venous blood plasma vitamin E levels by the Baker-Hatal method, ascorbic acid by the Teitz method, and SVD by the Beers-Seizer method. Results: The comparison of non-enzymatic oxidant parameters. Ascorbic acid, vitamin E, and the comparison of antioxidant enzymes SOD and GPX in both groups were statistically highly significant (p<0.00). Conclusion: It is proved that increased anti-oxidant enzymes except catalase and decreased non-enzymatic oxi-dants have diagnostic value in alcoholic liver disease patients.