Evaluating Advanced Transdermal Patches For Improved And Sustained Release Of Resveratrol

ABSTRACT Transdermal patches offer a novel approach for the controlled and sustained delivery of therapeutic agents, bypassing first-pass metabolism and improving bioavailability. This study explores the formulation and evaluation of resveratrol-loaded transdermal patches using hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC) as the primary polymers. The solvent casting method was employed for the preparation of the patches, incorporating glycerin as a plasticizer. The patches were assessed for various physical properties, including appearance, moisture content, thickness, folding endurance, and in vitro drug release. The in vitro drug release study demonstrated that the formulation F4 (Improved) exhibited the most efficient release, achieving 95% release at 24 hours. Fourier-transform infrared (FTIR) spectroscopy revealed the presence of key functional groups, confirming the stability and integrity of the active ingredients and excipients. All formulations exhibited favourable physical properties, with consistent moisture content (2.7–3.2%) and excellent folding endurance (>300). The results suggest that the F4 formulation is a promising candidate for enhanced drug delivery of resveratrol via transdermal patches. Further in vivo studies are necessary to assess its clinical efficacy.