Successful Pregnancy Following Endometrial Platelet-Rich Plasma (PRP) INFUSION in Advanced age Woman Repeated IVF Failure: A Case Report

Abstract Background: Endometrial platelet-rich plasma infusion is a promising treatment for women facing challenges with infertility. The use of PRP in the endometrium has gained attention due to its potential to improve endometrial receptivity and thickness to support embryo implantation. Case: A 41-year-old woman visited ALBARAKA FERTILITY HOSPITAL between 2008 and 2018 with a history of primary infertility for 2 years. Underwent an endometrial PRP infusion as a part of fertility (INFERTILITY) treatment after four unsuccessful embryo transfer attempts, which included two times on day 5 fresh embryo transfer, one time on day 3 frozen/thawed embryo transfer, and one time on day 3 thawed for day 5 frozen/thawed embryo transfer. After undergoing the procedure, the patient successfully achieved a clinical pregnancy. This case highlights the potential role of endometrial PRP infusion in improving endometrial receptivity and facilitating successful pregnancy outcomes. Conclusion: The successful pregnancy in this case suggests a potential benefit of endometrial PRP infusion in (advanced age) patient with repeated embryo transfer failure. Further research and clinical studies are warranted to elucidate the mechanisms and efficacy of PRP therapy in improving endometrial receptivity and enhancing fertility outcomes. Keywords: Recurrent implantation failure; endometrial thickness; platelet-rich plasma (PRP); frozen embryo transfer; implantation; receptivity.