Evaluation of the Role of Intra-Articular Platelet Rich Plasma Injection in Peri-Arthritis Shoulder

Background: Periarthritis shoulder is a disabling disease characterized by shoulder pain and limitations of both active and passive range of movement in all directions. It is the result of fibrosis and thickening of the joint capsule and adherence to the humeral head. Periarthritis can be managed using a variety of therapeutic techniques. Platelets rich plasma (PRP) is a concentrated platelet solution that degranulates alpha granules and includes a variety of growth factors, including cytokines that aid in soft tissue healing. Objective: The aim of the study was to evaluate the role of intra-articular PRP injection in patients with shoulder peri-arthritis. Methods: 31 patients (>40 year) with U/L or B/L frozen shoulder having pain more than or equal to two months were included. Shoulder mobilization was performed under short GA and full range of motion was achieved during the procedure followed by intra-articular injection of PRP (3ml) under all aseptic precaution with 20-gauge needle. Patients were reviewed & evaluated clinically on the basis of VAS and CSS score after 0, 2 and 4 weeks. Results: The mean age of the patients was 57.58 ± 8.67 years with predominance of females (64.5%). The mean duration of pain was 6.03 ± 4.18 months. There was a significant decrease (p=0.001*) in mean VAS scores at both 2- and 4-weeks post-treatment. Following the initiation of PRP therapy, there was a significant increase (p=0.001*) in the mean CSS score at 2- and 4-weeks post-treatment. Conclusion: Our study concluded that there was significant improvement in the pain as well as functional score after the PRP injection. Intra-articular PRP injection therapy with manipulation is a safe and effective treatment modality for periarthritis shoulder.