Review On Ethosomes Incorporated into Gel: A Novel Approach for Topical Delivery of Drug

The largest organ in the body, the skin, may be used to administer drugs for both local and systemic effects. However, the stratum corneum (SC), the skin's outermost layer, serves as a strong barrier that prohibit hydrophilic and high molecular weight medications from penetrating. One simple and easy solution is to incorporate medications in formulations with elastic vesicles or skin enhancers. The vesicular-shaped structures known as ethosomes are composed primarily of ethanol and phospholipids. Since they are nanometres in size and have a higher quantity of ethanol in their structure, they have demonstrated exceptionally significant drug penetration whether applied topically. The hot method and the cold method are the two main methods used to formulate the ethosomes. Furthermore, recently new method was developed for formulating ethosomes including classical mechanical dispersion method. Then formulated ethosomes incorporated into gel to carry ethosomes, deep penetration of drug into skin, stability and sustained release of ethosomes. Ethosomal gels offer a promising strategy for enhancing the delivery of drugs, improving their therapeutic efficacy and improve patient compliance. In this review article various aspect of ethosomes including their mechanism of penetration, advantages, composition, application, method of preparation, characterization of ethosomes and in ethosomal gel aspect like gelling agent, importance, examples of gelling agent and Characterization of ethosomal gel. These carriers pose new challenges and potential for the development of novel, better treatment.