Synthetic Immunology Inspired by Cross-Species Oncology: Engineering Human Cancer Immunity Through Peto's Paradox

This conceptual article proposes a synthetic immunology approach to cancer treatment, inspired by the cross-species analysis of large, long-lived animals that exhibit natural cancer resistance — a phenomenon known as Peto’s Paradox. By identifying and harnessing powerful tumor-suppressing genes such as TP53 and TNF variants from these species, the work outlines a strategy for genetically engineering human immune cells to enhance anticancer immunity. The paper presents a translational bridge between evolutionary oncology and next-generation immunotherapy.