Formulation and Characterization of Ethosomal Gel Containing Vitex Negundo Extract for Treatment of Arthritis

NSAIDs are great for arthritic pain but can have some unwanted complications like ulcers, bleeding kidney issues, and a higher chance of a heart complications. NSAID can even cause more stress on your body by making more reactive oxygen species. To overcome this problem therapeutic option is herbal medicine. Medicinal plants have intrinsic active substances to heal sickness or relieve pain. Leaves of Vitex negundo in the Verbenaceae family which show anti arthritic activity was used for preparation of ethosomes. In order to successfully formulate the ethosomes, a cold method was effectively used. 400 milligrams of soya lecithin, 14 milliliters of ethanol, and 200 milligrams of polyethylene glycol 4000 are the components that make up the ideal formulation. Transmission electron microscopy images exposed the circular shape then clarified the formation of ethosomes. Particle size, zeta potential was found to be 162.3 nm and -29 mV respectively. Entrapment efficiency of optimized batch was found to be 78.5%. Finally, prepared ethosomal gel system significantly enhance skin penetration and having sustained release for prolong duration of time.