UV Spectrophotometric Method Validation of Rosuvastatin Calcium in API and Pharmaceutical Dosage Form

UV spectrophotometric method is a simple, economical and sensitive procedure. This technique was used for determination of rosuvastatin calcium, an anti-hyperlipidemic drug in pharmaceutical formulation. The goal of this research is to compare the rosuvastatin calcium drug in pure form with the marketed tablet (Rozavel 10) by UV spectrophotometer. Beer Lambert’s law had been followed across concentration range 2-20 µg/ml in pH 6.8 and 7.4 phosphate buffers. Results of linear regression for pure drug had been determined as y = 0.0443x+0.0799, y = 0.0363x+0.058 and for marketed tablet it had been discovered to be y = 0.0375x+0.0537, y = 0.0369x+0.0816 in the above-mentioned phosphate buffers. According to ICH standards, the constructed method is statistically validated, and the results fulfill the requirements for acceptance.