RISK FACTORS FOR KIDNEY DAMAGE IN OSTEOPOROSIS WITH HEART FAILURE

Recent studies have demonstrated a high risk of kidney damage andassociated cardiovascular complications in patients with Osteoporosis whichgenerally determines the prognosis of these patients. However, the frequency ofchronic kidney disease (CKD) in Osteoporosis in the Uzbekistan cohort of patientshas not been precisely established. The unfavorable prognostic significance ofkidney damage in rheumatoid arthritis (RA) has been actively attracting the attentionof researchers in recent years. Certain clinical variants of involvement of the kidneysin the pathological process in rheumatoid arthritis are noted in most patients. Variousvariants of kidney damage in rheumatoid arthritis are described, in particular,glomerulonephritis, amyloidosis, vasculitis, as well as iatrogenic forms (analgesictubulopathy, membranous nephropathy, etc.). It is noteworthy that in real clinicalconditions, morphological verification of renal pathology may not be performed fora long time in such patients for a number of objective reasons. Early manifestationsof functional renal disorders, especially with their moderate severity, do not alwaysattract the attention of clinicians, while the progression of chronic kidney disease(CKD) in Osteoporosis can be Osteoporosis, especially in old age, as well as inassociation with cardiovascular pathology. The formation of nephropathy inOsteoporosis has a complex multifactorial character and manifests itself in variousclinical and morphological variants. Thus, various clinical forms of kidney damagein Osteoporosis are known (amyloidosis, glomerulonephritis, less often rheumatoidgranulomatosis and rheumatoid renal vasculitis), as well as iatrogenic, due toongoing treatment (medicinal tubulointerstitial nephritis, membranous nephropathy,mesangioproliferative glomerulonephritis). At the same time, in real clinicalpractice, the nosological diagnosis of kidney disease in Osteoporosis is usuallyestablished when clinical and laboratory criteria appear, the most important of whichis proteinuria, at the same time, it has recently been established that with a lowsymptomatic course, renal dysfunction can develop without the presence ofproteinuria. It is noteworthy that rheumatologists do not always pay attention to theearly manifestations of functional renal disorders, especially with moderate severityof proteinuria, although the Osteoporosiste of decline in kidney function inAmerican Jurnal Of Advanced Scientific Research | ISSN 2195- 1381 | Volume – 4 | May-2025AMERICAN JURNAL OF ADVANCEDSCIENTIFIC RESEARCHISSN 2195-1381 Volume- 4 May 2025https://journal-index.org/index.php/ajasr367Osteoporosis can be quite fast, especially in old age and in association withcardiovascular pathology.