RESEARCH ON THE DEVELOPMENT OF COMPOSITIONS AND TECHNOLOGY FOR NEVIRAPIN CAPSULES

This article presents the results of research aimed at selecting the optimal composition and developing the technology of nevirapine capsules with antiretroviral action. For this purpose, model capsules were developed using various fillers and auxiliary substances acting as disintegrators, and they were evaluated based on pharmaco-technological indicators. It has been proven that it is advisable to use a mixture of lactose and microcrystalline cellulose, a mixture of crospovidone and aerosil as a filler, an antifriction agent - magnesium stearate, and a moisturizing agent - purified water. Based on the selected composition, the technology of nevirapine capsules was developed and tested in industrial conditions at the local pharmaceutical manufacturer JV LLC “Samarkand-England Eco-Medical”.