METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN, EZETIMIBEIN AND FENOFIBRATE BULK AND PHARMACEUTICAL DOSAGE FORMS BY RP-HPLC

RP-HPLC method was developed and validated as per ICH guidelines for the estimation of. Atorvastatin, Ezetimibe and Fenofibrate Simultaneous Estimation of Atorvastatin, and Ezetimibe were carried out by RP- HPLC using potassium dihydrogen orthophosphate buffer & acetonitrile, and C18 G analytical columnas a stationary phase and peak was observed at 265 nm which was selected as a wavelength for quantitative estimation. After the development of the method, it was validated for various parameters. It was found that recovery value of pure drug was between 99 % to 101% which indicates that the method is accurate and also reveals that commonly used excipients and additives present in the pharmaceutical formulations were not interfering in the proposed methods. The ruggedness of the method was checked by different analysts and found that the results were nearly same which indicates that the method is rugged. Based on the results observed, it was concluded that proposed method can be used for routine analysis of Atorvastatin , Ezetimibe and Fenofibrate Key words: Atorvastatin and Ezetimibe, Fenofibrate ,linearity, accuracy, precision.