CLINICAL PHARMACOLOGICAL APPROACH TO THE USE OF ANTIBIOTICS IN CHILDREN

Knowledge of the pharmacokinetic and pharmacodynamic profile of an antibacterial drug is critical for optimizing the dosage regimen. The strategy of individual selection of the dosage regimen taking into account the principles of pharmacokinetics and pharmacodynamics can be especially effective in patients with expectedly altered pharmacokinetic parameters and in infections caused by bacterial strains with low sensitivity to antibiotics. The review presents current concepts of the pharmacokinetic and pharmacodynamic profile of antibacterial drugs most frequently used in pediatrics and their relationship with the clinical efficacy of the therapy.