Solubility Enhancement of Dicofenac Sodium by Mixed Solvency Method: A Novel Approach

Diclofenac sodium is a poorly water soluble drug that has shown enhanced solubility using mixed solvency approach. It involves the combination of different blends of solubilizer to improve the drug's solubility. Poor water soluble drug obtain, causes significant problem in producing formulation of sufficiently high bioavailability, effective use of the drugs. The blends of randomly selected solubilizer are sodium acetate, PEG 200, sodium lauryl sulfate, sodium citrate, sodium benzoate. The present investigation of mixed solvency approach has been applied for enhancement of aqueous solubility of poorly water- soluble drug diclofenac sodium. The purpose of the presence study was to examine and compare the co solvency using different co-solvents.